Glucocorticoids and foetal heart maturation; implications for prematurity and foetal programming
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چکیده
منابع مشابه
Glucocorticoids and foetal heart maturation; implications for prematurity and foetal programming.
Glucocorticoids are steroid hormones, essential in mammals to prepare for life after birth. Blood levels of glucocorticoids (cortisol in most mammals including humans; corticosterone in rats and mice) rise dramatically shortly before birth. This is mimicked clinically in the routine administration of synthetic glucocorticoids to pregnant women threatened by a preterm birth or to preterm infants...
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Glucocorticoids are vital for the structural and functional maturation of foetal organs, yet excessive foetal exposure is detrimental to adult cardiovascular health. To elucidate the role of glucocorticoid signalling in late-gestation cardiovascular maturation, we have generated mice with conditional disruption of glucocorticoid receptor (GR) in cardiomyocytes and vascular smooth muscle cells u...
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ژورنال
عنوان ژورنال: Journal of Molecular Endocrinology
سال: 2013
ISSN: 0952-5041,1479-6813
DOI: 10.1530/jme-13-0204